Dystrophin (DMD) (Marker of Duchenne and Becker Muscular Dystrophy) Antibody

Product Sizes

100 ug

£671.00

1756-MSM1-P1-100UG

About this Product

SKU:: 1756-MSM1-P1
Application:: ELISA, Immunohistochemistry
translate.label.attr.clone:: DMD/3241
Clonality:: Monoclonal
Extra Details:: Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix; through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases; has more than 80 exons; produces a 14 kb mRNA and contains at least 8 independent tissue-specific promoters and 2 poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002% of total striated muscle protein and localizes to triadic junctions in skeletal muscle; where it is thought to influence calcium ion homeostasis and force transmission.
Host:: Mouse
Immunogen:: A recombinant fragment (around aa 114-263) of human DMD protein (exact sequence is proprietary)
Isotype:: IgG1
Molecular Weight:: 427kDa
Research Area:: Cardiovascular
Shipping Conditions:: Blue Ice
Storage Conditions:: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:: NeoBiotechnologies
Type:: Antibodies: Monoclonal Antibody

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