DCP2 (Decapping mRNA 2) Antibody
Product Sizes
20 ug
£364.00
167227-MSM1-P0-20UG
About this Product
- SKU:
- 167227-MSM1-P0
- Additional Names:
- Nucleoside diphosphate-linked moiety X motif 20 | mRNA-decapping enzyme 2
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-DCP2-1D6
- Clonality:
- Monoclonal
- Extra Details:
- The major pathway of eukaryotic mRNA decay involves deadenylation-dependent decapping followed by 5' to 3'exonucleolytic degradation. Human decapping enzyme 2 (hDcp2) is an mRNA decapping enzyme which contains intrinsic decapping activity. In nonsense-mediated decay; the human decapping complex; made up of hDcp1 and hDcp2; may be recruited to mRNAs containing premature termination codons by nonsense-mediated decay factor (Upf) proteins. The decapping activator complex (Lsm1p-7p) is also involved in the recruitment of the decapping complex; indicated by data showing that Lsm1p-7p enhances the co-immunoprecipitation of the complex with mRNA. Dcp2 specifically hydrolyzes methylated capped RNA to release m7GDP; thereby aiding in mRNA degradation. Both Dcp1 and Dcp2 co-localize in the cytoplasm; which is consistent with their role in mRNA decay
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human DCP2protein
- Isotype:
- IgG2a
- Molecular Weight:
- 48.4kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=112864
