DBH / Dopamine Beta-Hydroxylase Antibody

Product Sizes

100 ug

£671.00

1621-MSM2-P1ABX-100UG

About this Product

SKU:: 1621-MSM2-P1ABX
Additional Names:: Dopamine beta-monooxygenase
Application:: Immunohistochemistry
translate.label.attr.clone:: DBH/7222
Clonality:: Monoclonal
Extra Details:: Dopamine Œ≤-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline in the biosynthesis of catecholamines. DBH is selectively expressed in noradrenergic and adrenergic neurons; as well as in neuroendocrine cells; and it serves as a specific protein marker for noradrenergic processes. The active form of DBH is a homotetramer; which is found in the lumen of synaptic vesicles of corresponding nerve cells; where it localizes to both the membrane and cytosol. DBH is induced by nerve growth factor and Insulin growth factor-1 and is regulated by intracellular second messengers protein kinase A; cyclic AMP; diacyl glycerol and Ca2+. Expression of DBH is transcriptionally mediated by Sp1; CREB and AP-1 proteins including c-Fos; c-Jun and JunD.
Host:: Mouse
Immunogen:: Recombinant fragment (around aa200-400) of human DBH protein (exact sequence is proprietary)
Isotype:: IgG2
Molecular Weight:: 78/84 kDa
Research Area:: Cardiovascular; Neuroscience
Shipping Conditions:: Blue Ice
Storage Conditions:: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:: NeoBiotechnologies
Type:: Antibodies: Monoclonal Antibody

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