Recombinant p120 / Catenin; delta-1 (CTNND1) Antibody
Product Sizes
100 ug
£671.00
1500-MSM13-P1ABX-100UG
About this Product
- SKU:
- 1500-MSM13-P1ABX
- Additional Names:
- Cadherin-associated Src substrate | p120 catenin | p120(cas)
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- rCTNND1/6903
- Clonality:
- Monoclonal
- Extra Details:
- Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site. The complex stabilizes tight junctions. In the cell; p120 catenin localized to the E-cadherin/catenins cell adhesion complex; directly associates with cytoplasmic C-terminus of E-cadherin and may similarly interact with other cadherins. p120 is a proliferation-associated nucleolar protein found in most human malignant tumors; but not in resting normal cells. In colorectal cancer the altered localization of p120 catenin corresponds with loss of cytoplasmic localization of E-cadherin. Studies have shown accurate categorization of ductal vs. lobular neoplasia in the breast was achieved with p120 staining. p120 expression further clarifies the separation of low-grade ductal carcinoma in situ from lobular neoplasia. Studies also have shown that altered expression of p120 catenin antibody predicts poor outcome in invasive breast cancer.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa868-968) of human p120 (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 120kDa
- Research Area:
- BBB VCAM-1 Signaling; Cardiovascular; Infectious Disease; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=112713
