Catenin; delta-1 (CTNND1) (pTyr96) Antibody
Product Sizes
100 ug
£671.00
1500-MSM1-P1-100UG
About this Product
- SKU:
- 1500-MSM1-P1
- Additional Names:
- Cadherin-associated Src substrate | p120 catenin | p120(cas)
- Application:
- ELISA, Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- 25a
- Clonality:
- Monoclonal
- Extra Details:
- The membrane associated protein pp120 Src substrate (p120 Catenin; p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. Its characteristic Arm domain that is composed of 42-amino acid motif repeats evidences this similarity. In the cell; p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin; p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115kDa. Expression of these isoforms is heterogeneous in human carcinomas; suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96; Y112; Y228; Y280; Y257; Y291; Y296; and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus; p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules; such as cadherins and cell signaling molecules; such as PTP1C.
- Host:
- Mouse
- Immunogen:
- Mouse p120 Catenin (pY96)
- Isotype:
- IgG1
- Molecular Weight:
- 120kDa
- Research Area:
- BBB VCAM-1 Signaling; Cardiovascular; Infectious Disease; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=112711
