Recombinant Catenin; beta (CTNNB1) Antibody
Product Sizes
100 ug
£671.00
1499-RBM17-P1ABX-100UG
About this Product
- SKU:
- 1499-RBM17-P1ABX
- Additional Names:
- Beta-catenin
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- CTNNB1/7044R
- Clonality:
- Monoclonal
- Extra Details:
- Beta-catenin associates with the cytoplasmic portion of E-cadherin; which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues; beta-catenin is localized to the membrane of epithelial cells; consistent with its role in the cell adhesion complex. In breast ductal neoplasia; beta-catenin is usually localized in cellular membranes. However; in lobular neoplasia; a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms; including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally; some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining; mimicking the staining pattern observed with lobular breast carcinomas.
- Host:
- Rabbit
- Immunogen:
- Recombinant full-length human β-catenin protein
- Isotype:
- IgG
- Molecular Weight:
- 92kDa
- Research Area:
- BBB VCAM-1 Signaling; Basal Cell Marker; Breast Cancer; Cardiovascular; Colon Cancer; Developmental Biology; Immunology; Infectious Disease; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=112686
