Recombinant CTLA4 / CD152 (Negative Regulator of T-Cells) Antibody
Product Sizes
100 ug
£671.00
1493-RBM7-P1ABX-100UG
About this Product
- SKU:
- 1493-RBM7-P1ABX
- Additional Names:
- Cytotoxic T-lymphocyte-associated antigen 4
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- CTLA4/6867R
- Clonality:
- Monoclonal
- Extra Details:
- Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a member of the CD28 superfamily and is a negative regulator of T cell-mediated immune responses. CTLA-4 expression is induced on the surface of T cells after CD28 binding and activation; and is constitutively expressed on T-regulatory cells; acting as an immune checkpoint inhibitor; downregulating T cell activity. CTLA-4 primarily inactivates T-cell activity by competing with the CD28 costimulatory molecule. CD28 and CTLA-4 share the identical ligands of CD80 and CD86 on antigenpresenting cells; and thus CTLA-4 competes with CD28 function in T-cell survival; proliferation; and recruitment. In particular; CTLA-4 down-modulates CD4+ helper T-cell activity and enhances Treg immunosuppressive functions. CTLA-4 has been shown to play a role in human diseases. CTLA-4 acts as a physiological brake on the activated immune system in order to maintain immune homeostasis. Several suppressive mechanisms for T-cell functions have been attributed to CTLA-4.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment of human CTLA4 (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 30-43kDa
- Research Area:
- CTLA-4 blockade immunotherapy; Cardiovascular; Immunology; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=128495
