CTLA4 / CD152 (Negative Regulator of T-Cells) Antibody
Product Sizes
100 ug
£671.00
1493-MSM1-P1-100UG
About this Product
- SKU:
- 1493-MSM1-P1
- Additional Names:
- Cytotoxic T-lymphocyte-associated antigen 4
- Application:
- Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- L4P2F5.F10
- Clonality:
- Monoclonal
- Extra Details:
- CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain; a transmembrane domain; and a cytoplasmic tail. Alternate transcriptional splice variants; encoding different isoforms; have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond; while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus; Graves disease; Hashimoto thyroiditis; celiac disease; systemic lupus erythematosus; thyroid-associated orbitopathy; and other autoimmune diseases.The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule.
- Host:
- Mouse
- Immunogen:
- A synthetic peptide from CTLA4 (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 30-43kDa
- Research Area:
- CTLA-4 blockade immunotherapy; Cardiovascular; Immunology; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=112625
