Crystallin Alpha B Antibody
Product Sizes
20 ug
£364.00
1410-MSM18-P0-20UG
About this Product
- SKU:
- 1410-MSM18-P0
- Additional Names:
- Alpha(B)-crystallin | Heat shock protein beta-5 | Renal carcinoma antigen NY-REN-27 | Rosenthal fiber component
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- CRYAB/7918
- Clonality:
- Monoclonal
- Extra Details:
- Crystallins are the major proteins of the vertebrate eye lens; where they maintain the transparency and refractive index of the lens. Crystallins are divided into α; β and γ families; and the β- and γ-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions; including four homologous motifs; a connecting peptide and N- and C-terminal extensions. α-crystallins consist of three gene products; αA-; αB- and αC-crystallin; which are members of the small heat shock protein family (HSP 20). α-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However; unlike other molecular chaperones; α-crystallins do not renature these proteins. Expression of αA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human αB-crystallin gene product is expressed in many tissues; including lens; heart and skeletal muscle. Elevated expression of αB-crystallin is associated with many neurological diseases; and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length CRYAB protein
- Isotype:
- IgG1
- Molecular Weight:
- Predicted: 20kDa; Observed: 22-30kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=128494
