Recombinant CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody
Product Sizes
20 ug
£364.00
1373-RBM32-P0-20UG
About this Product
- SKU:
- 1373-RBM32-P0
- Additional Names:
- Carbamoyl-phosphate synthetase I
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- CPS1/13326R
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes a protein of 165kDa; identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle; which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach; but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly; strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally; CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
- Host:
- Rabbit
- Immunogen:
- Recombinant full-length human CPS1 protein
- Isotype:
- IgG
- Molecular Weight:
- ~165kDa
- Research Area:
- Cardiovascular; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=143841
