CD195 (CC-Chemokine Receptor 5) Antibody
Product Sizes
20 ug
£364.00
1234-MSM1-P0-20UG
About this Product
- SKU:
- 1234-MSM1-P0
- Additional Names:
- CHEMR13 | HIV-1 fusion coreceptor
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry
- translate.label.attr.clone:
- 12D1
- Clonality:
- Monoclonal
- Extra Details:
- Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family; and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells; macrophages; NK cells; and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor; CCR5 plays a critical role in HIV entry into the target cells. Moreover; the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha; MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection; making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases; ranging from infectious and inflammatory diseases to cancer.
- Host:
- Mouse
- Immunogen:
- Human native CCR5 protein
- Isotype:
- IgG2a
- Molecular Weight:
- 45kDa
- Research Area:
- AKT Signaling; Cardiovascular; Cytokine Signaling; Immunology; Infectious Disease; Mast Cell Marker; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=112382
