SPI-C / Transcription factor Spi-C Antibody
Product Sizes
20 ug
£364.00
121599-MSM3-P0-20UG
About this Product
- SKU:
- 121599-MSM3-P0
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-SPIC-2C5
- Clonality:
- Monoclonal
- Extra Details:
- The Ets transcription factor family is comprised of DNA-binding proteins that influence lymphoid development and activity and bind the consensus DNA site GGA(A/T) through a unique winged helix-turn-helix motif known as the Ets domain. Spi-B and Spi-C (also known as SPIC) are closely related Ets family members which share a conserved divergent sequence within the Ets domain that enables their binding to non-canonical AGAA sites. Spi-C is a 248 amino acid protein that localizes to the nucleus and; like other Ets family members; binds DNA as a monomer and plays a role in transcriptional regulation. Addi- tionally; Spi-C is thought to control the development of red pulp macrophages; thereby contributing to iron homeostasis and red blood cell recycling. Human Spi-C shares 65% amino acid identity with its mouse counterpart; suggesting a conserved role between species.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human SPIC protein
- Isotype:
- IgG2b
- Molecular Weight:
- 29kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=112353
