Clusterin / Apolipoprotein J (APO-J) Antibody
Product Sizes
100 ug
£671.00
1191-MSM17-P1-100UG
About this Product
- SKU:
- 1191-MSM17-P1
- Additional Names:
- Aging-associated gene 4 protein | Apolipoprotein J | Complement cytolysis inhibitor | Complement-associated protein SP-40;40 | Ku70-binding protein 1 | NA1/NA2 | Sulfated glycoprotein 2 | Testosterone-repressed prostate message 2
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- CLU/4737
- Clonality:
- Monoclonal
- Extra Details:
- Clusterin; also designated complement lysis inhibitor (CLI); apolipoprotein J (APOJ); sulfated glycoprotein 2 (SGP2); SP40 and testosterone-repressed prostate message 2 (TRPM2); is a secretory; heterodimeric glycoprotein that influences immune regulation; cell adhesion; transformation; lipid transportation; tissue remodeling; membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid polypeptide that is post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits; 伪 and 尾; are associated through disulfide bonds. The 尾 subunit (also called ApoJ伪) corresponds to residues 23-227. The 伪 subunit (also called ApoJ尾) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences 尾-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer s pathogenesis.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa150-300) of human CLU protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 70kDa (precursor); 36-39kDa (伪); 34-36kDa (尾)
- Research Area:
- Cardiovascular; Complement System; Immunology; Neuroscience
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=139223
