CHEK2 Antibody
Product Sizes
100 ug
£671.00
11200-MSM3-P1ABX-100UG
About this Product
- SKU:
- 11200-MSM3-P1ABX
- Additional Names:
- CHK2 checkpoint homolog | Cds1 homolog | Checkpoint kinase 2
- Application:
- Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- PCRP-CHEK2-1A4
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a serine/threonine protein kinase that is a required check-point to mediate cell cycle arrest; activation of DNA repair and apoptosis.In response to DNA damage and replication blocks; cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated; the encoded protein is known to inhibit CDC25C phosphatase; preventing entry into mitosis; and has been shown to stabilize the tumor suppressor protein p53; leading to cell cycle arrest in G1. Also; this protein interacts with and phosphorylates BRCA1; allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome; a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Mutations in this gene are thought to confer a predisposition to sarcomas; breast cancer; and brain tumors.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human CHEK2 corresponding to protein domain
- Isotype:
- IgG2b
- Molecular Weight:
- 60.91kDa
- Research Area:
- Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=112176
