Chromogranin B / CHGB (Neuroendocrine Marker) Antibody
Product Sizes
100 ug
£671.00
1114-MSM6-P1-100UG
About this Product
- SKU:
- 1114-MSM6-P1
- Additional Names:
- Chromogranin-B | Secretogranin I
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- CHGB/7756
- Clonality:
- Monoclonal
- Extra Details:
- Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine; neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A); chromogranin B (Chr-B; also known as secretogranin I) chromogranin C (also known as secretogranin II or Sg II); secretogranin III (Sg III or SCG3). High levels of Chr-A expression is a characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits Insulin secretion; exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms; the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine; while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland; Sg III is present in mammotropes and thyrotropes; moderately in gonadotropes and corticotropes; though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa250-450) of human CHGB protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 76/110kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=132661
