Fas (TNFRSF6) associated factor 1 Antibody
Product Sizes
100 ug
£671.00
11124-MSM1-P1-100UG
About this Product
- SKU:
- 11124-MSM1-P1
- Additional Names:
- UBX domain-containing protein 12 | UBX domain-containing protein 3A
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- CPTC-FAF1-2
- Clonality:
- Monoclonal
- Extra Details:
- In contrast to growth factors which promote cell proliferation; FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved 'death domain' and belonging to the TNF receptor superfamily. TRADD; FADD and RIP are FAS/TNF-RI interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-RI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-RI via their DDH regions; while RIP associates exclusively with FAS. An additional FAS interacting protein designated FAF1; for FAS-associated protein factor-1; binds with the cytoplasmic tail of wildtype but not LPR mutant FAS. When overexpressed in cells; FAF1 enhances the efficiency of FAS-mediated apoptosis. In contrast to TRADD; FADD and RIP; FAF1 lacks a DDH and cannot induce apoptosis independently of FAS activation.
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length FAF1 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 75-80kDa
- Research Area:
- Apoptosis; Autophagy; Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=112082
