MerTK (Innate Immune Checkpoint) Antibody
Product Sizes
100 ug
£671.00
10461-MSM2-P1ABX-100UG
About this Product
- SKU:
- 10461-MSM2-P1ABX
- Additional Names:
- Proto-oncogene c-Mer | Receptor tyrosine kinase MerTK
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MERTK/3022
- Clonality:
- Monoclonal
- Extra Details:
- MerTK; also called c-Mer; is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain; two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation; platelet aggregation; clot stability and the efficient removal of apoptotic cells. Specifically; MerTK acts as a signaling molecule; triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 纬2 (PI-PLC 纬2). When the gene encoding for MerTK is mutated; the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result; leading to degeneration of retinal photoreceptor cells.
- Host:
- Mouse
- Immunogen:
- Recombinant human MERTK protein fragment (around aa 55-148) (exact sequence is proprietary)
- Isotype:
- IgG2a
- Molecular Weight:
- 110kDa
- Research Area:
- AKT Signaling; Complement System
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=111725
