SMNDC1 Antibody
Product Sizes
100 ug
£671.00
10285-MSM2-P1ABX-100UG
About this Product
- SKU:
- 10285-MSM2-P1ABX
- Additional Names:
- 30 kDa splicing factor SMNrp | SMN-related protein | Survival motor neuron domain-containing protein 1
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-SMNDC1-1A9
- Clonality:
- Monoclonal
- Extra Details:
- SPF30 (survival of motor neuron-related-splicing factor 30); also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein); is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle; pancreas and heart; localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition; the overexpression of SPF30 can lead to apoptosis.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human SMNDC1 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 30kDa
- Research Area:
- Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=111636
