p27Kip1 (Mitotic Inhibitor/Suppressor Protein) Antibody
Product Sizes
0.5 ml at 100ug/ml
£671.00
1027-MSM2-CF488-100T-0.5MLAT100UG
About this Product
- SKU:
- 1027-MSM2-CF488-100T
- Additional Names:
- Cyclin-dependent kinase inhibitor p27 | p27Kip1
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- KIP1/769
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes a 27kDa protein; identified as the p27Kip1; a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. In Western blotting of cell lysates from 7 human breast cancer cell lines (ZR75-1; ZR75-30; MCF-7; MDAMB453; T47D; CAL51; 734B); the antibody labels a single band corresponding to p27Kip1. It functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. Reportedly; low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma; colon carcinoma; breast carcinomas; non-small-cell lung carcinoma; hepatocellular carcinoma; multiple myeloma; and lymph node metastases in papillary carcinoma of the thyroid; as well as a more aggressive phenotype in carcinoma of the cervix.
- Host:
- Mouse
- Immunogen:
- Recombinant human KIP1 protein
- Isotype:
- IgG1
- Molecular Weight:
- 25-26kDa
- Research Area:
- AKT Signaling; Cancer; Cardiovascular; Cytokine Signaling; Hypoxia; Immunology; Infectious Disease; Lung Cancer; Nuclear Marker; Ovarian Cancer; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 4 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=126741
