Recombinant p27Kip1 (Mitotic Inhibitor / Suppressor Protein) Antibody
Product Sizes
20 ug
£364.00
1027-MSM12-P0-20UG
About this Product
- SKU:
- 1027-MSM12-P0
- Additional Names:
- Cyclin-dependent kinase inhibitor p27 | p27Kip1
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- r1B4
- Clonality:
- Monoclonal
- Extra Details:
- p27 protein; also known as kinase inhibitory protein 1 (Kip1); is a polypeptide which binds to cyclin E/cdk2 complexes (but not to cdk2 alone) and is detected in purified extracts of growth-arrested cells. p27 protein constrains cell proliferation by setting the threshold level of cyclin E necessary to activate cdk2. The 27kD protein is also present in proliferating cells but only in a sequestered form when it is unavailable to interact with cyclin E/cdk2 complexes. It is likely that cyclin D complexed with catalytically inactive cdk4 is sufficient to sequester p27 and titrate its function. The presence of bound p27 in proliferating cells suggests that its role may not be restricted to inducing cell cycle arrest but to also set the cyclin E threshold for execution of the G1 to S phase transition during each mitotic cycle.
- Host:
- Mouse
- Immunogen:
- Prokaryotic recombinant antigen corresponding to the full length p27 molecule
- Isotype:
- IgG2a
- Molecular Weight:
- 25-26kDa
- Research Area:
- AKT Signaling; Cancer; Cardiovascular; Cytokine Signaling; Immunology; Infectious Disease; Lung Cancer; Nuclear Marker; Ovarian Cancer; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=141547
