EBI3 / Epstein-Barr virus induced 3 Antibody
Product Sizes
20 ug
£364.00
10148-MSM6-P0-20UG
About this Product
- SKU:
- 10148-MSM6-P0
- Additional Names:
- Epstein-Barr virus-induced gene 3 protein
- Application:
- ELISA, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- EBI3/8906
- Clonality:
- Monoclonal
- Extra Details:
- Epstein-Barr virus-induced gene 3 (Ebi3) is a widely expressed homolog to the interleukin IL-12 p40 subunit protein that forms a heterodimer with either IL-12 p35 or an IL-12 p35 homolog; p28; to create a new cytokine (IL-27). IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4+ T cells. Interferon-b differentially regulates expression of the IL-12 family members p35; p40; p19 and Ebi3 in activated human dendritic cells. Ebi3 may function to antagonize IL-12 and to inhibit the development of a Th1 immune response. Ebi3 is strongly expressed in Hodgkin and Reed-Sternberg cells; independently of the EBV status of the tumor cells. Research suggests that Ebi3 may be an additional component of the repertoire employed by Hodgkin and Reed-Sternberg cells to inhibit an effective anti-tumor or anti-viral immune response. The human Ebi3 gene maps to chromosome 19p13.3 and encodes a secreted glycoprotein that is expressed in spleen and tonsils; and at high levels in full-term placenta.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 366-466) of human EBI3 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 34 kDa
- Research Area:
- Cytokine Signaling; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=135019
