PTPRU Antibody
Product Sizes
100 ug
£671.00
10076-MSM3-P1-100UG
About this Product
- SKU:
- 10076-MSM3-P1
- Additional Names:
- Pancreatic carcinoma phosphatase 2 | Protein-tyrosine phosphatase J | Protein-tyrosine phosphatase pi | Protein-tyrosine phosphatase receptor omicron | Receptor-type protein-tyrosine phosphatase psi
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- PTPRU/7616
- Clonality:
- Monoclonal
- Extra Details:
- Protein tyrosine phosphatases; or PTPs; are type I transmembrane proteins; membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR; PTPa; PTPb; PTPg; PTPd; PTPe; PTPz; PTPk; PTPm and PTPy. Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues. PTPy; also known as PTPRU; FMI; PCP-2; PTP-J; PTPRO; PTP-PI; PTPPSI or GLEPP1; is a receptor-type PTP containing a transmembrane region; two intracellular tandem catalytic domains; and an extracellular region with Ig-like and fibronectin type III-like repeats and a MAM (meprin-A5 antigen-PTPm) domain. PTPy localizes to adheren junctions and is capable of binding and dephosphorylating b-catenin thereby functioning as a negative regulator of b-catenin signaling. In addition; PTPy may function as a tumor suppressor; as its expression is silenced in a variety of tumors via methylation of its promoter.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human PTPRU protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 162kDa
- Research Area:
- Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=126985
