Occludin (Marker of Early Blood Brain Barrier Damage) Antibody
Product Sizes
100 ug
£768.00
100506658-MSM29-P1-100UG
About this Product
- SKU:
- 100506658-MSM29-P1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MSVA-415M
- Clonality:
- Monoclonal
- Extra Details:
- Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids; increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue; Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Occludin is a tight junction protein that is a key structural component of the blood-brain barrier (BBB). Degradation of Occludin is frequently seen in ischemic stroke and contributes to BBB disruption.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human Occludin protein (around aa 282-415) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 60-82kDa
- Research Area:
- BBB VCAM-1 Signaling; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=147536
