Recombinant N-Cadherin / Cadherin-2 / CD325 (NCAD) Antibody
Product Sizes
100 ug
£671.00
1000-RBM5-P1-100UG
About this Product
- SKU:
- 1000-RBM5-P1
- Additional Names:
- CDw325 | Neural cadherin
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- CDH2/3874R
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of ~140kDa; identified as N-Cadherin (NCAD); also known as CD325. NCAD is a member of the Cadherin superfamily; and consists of five extracellular repeats; a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this; CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm; establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore; CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells.Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.
- Host:
- Rabbit
- Immunogen:
- Recombinant full-length human CDH2 protein
- Isotype:
- IgG
- Molecular Weight:
- 130-140kDa
- Research Area:
- Cardiovascular; Developmental Biology; Mesenchymal Stem Cell Differentiation
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=111395
