Rabbit anti-MDR1 / P Glycoprotein 1 antibody, clone SQab30342 (monoclonal)
Product Sizes
100 ul
£671.00
MON240312-100UL
About this Product
- SKU:
- MON240312
- Application:
- IHC-Paraffin
- translate.label.attr.clone:
- SQab30342
- Clonality:
- Monoclonal
- Extra Details:
- Application note: Storage instruction: For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
- Host:
- Rabbit
- Immunogen:
- Recombinant protein fragment of MDR1 / P Glycoprotein 1
- Purification:
- Protein A Purified; Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Monosan
- Type:
- Antibody: Monoclonal Antibody
