CD3 epsilon antibody [APA1/1] (APC)
Product Sizes
100 ug
£403.00
GTX80236-07-100UG
About this Product
- SKU:
- GTX80236-07
- Additional Names:
- CD3E , CD3e molecule , IMD18 , T3E , TCRE , CD3 epsilon
- Application:
- Flow Cytometry
- Buffer:
- PBS, 15mM Sodium azide.
- translate.label.attr.clone:
- APA1/1
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Concentration:
- 0.1 mg/ml
- Extra Details:
- The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
- Host:
- Mouse
- Immunogen:
- Purified human CD3 proteins isolated from thymus
- Isotype:
- IgG1
- Physical State:
- Liquid
- Purification:
- Size-exclusion Chromatography
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody recognizes an activation-dependent intracellular epitope of CD3 epsilon. Exposure of the epitope precedes CD3 phosphorylation and recruitment and activation of ZAP70, which initiates the signaling cascade produced by T-cell activation. APA1/1 provides the earliest known marker for TCR-mediated T cell activation.
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- GeneTex
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:Download
