Human HAAO protein, His tag
Product Sizes
50 ug
GTX68330-PRO-50UG
About this Product
- SKU:
- GTX68330-PRO
- Additional Names:
- 3-hydroxyanthranilate 3,4-dioxygenase , 3-HAO , HAO , VCRL1 , h3HAO
- Buffer:
- 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, 1mM DTT, no preservatives.
- Concentration:
- 0.5 mg/ml
- Extra Details:
- 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
- Immunogen:
- 3-hydroxyanthranilate 3,4-dioxygenase
- Physical State:
- Liquid
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- GeneTex
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
- Manufacturer's Data Sheet:Download
