Her2 / ErbB2 antibody [IHC002]
Product Sizes
500 ul
£579.00
GTX57184-500UL
About this Product
- SKU:
- GTX57184
- Additional Names:
- Erb-B2 Receptor Tyrosine Kinase 2 , Cd340 , Her-2 , Her-2/Neu , Her2 , Mln 19 , Neu , Ngl , Tkr1 , Erbb2
- Application:
- IHC-Paraffin
- Buffer:
- Tris, 1% BSA, 0.09% Sodium azide.
- translate.label.attr.clone:
- IHC002
- Clonality:
- Monoclonal
- Extra Details:
- This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
- Host:
- Mouse
- Immunogen:
- Recombinant Human Her2/Neu protein.
- Isotype:
- IgG2a
- Physical State:
- Liquid
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- GeneTex
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:Download
