Factor XIIIa antibody [F13A1/1448]
Product Sizes
100 ug
£578.00
GTX34714-100UG
About this Product
- SKU:
- GTX34714
- Additional Names:
- F13A , F13A1 , coagulation factor XIII A chain , Factor XIIIa , Factor XIII A
- Application:
- Detection/Quantitation, ELISA, Flow Cytometry, IHC-Paraffin, Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- PBS, 0.05% BSA, 0.05% Sodium azide.
- translate.label.attr.clone:
- F13A1/1448
- Clonality:
- Monoclonal
- Concentration:
- 0.2 mg/ml
- Extra Details:
- This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human Factor XIIIa protein (aa46-181) (exact sequence is proprietary)
- Isotype:
- IgG2b
- Physical State:
- Liquid
- Purification:
- protein a/g purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- GeneTex
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:Download
