APAF1 peptide
Product Sizes
50 ug
£196.00
GTX27873-50UG
About this Product
- SKU:
- GTX27873
- Additional Names:
- Apoptotic Peptidase Activating Factor 1 , Apaf-1 , Ced4 , Apaf1
- Application:
- Block/Inhibit/Neutralise
- Buffer:
- PBS, 0.1% BSA, 0.02% Sodium azide.
- Concentration:
- 0.20 mg/ml
- Extra Details:
- Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homolog of the key cell death gene CED 4 in C. elegans was identified recently from human and mouse and designated APAF1 for Apoptosis protease-activating factor 1. APAF1 binds to Cytochrome c (APAF2) and Caspase 9 (APAF3), which leads to Caspase 9 activation. Activated Caspase 9 in turn cleaves and activates Caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. APAF1 can also associate with Caspase 4 and Caspase 8. APAF1 transcript is ubiquitously expressed in human tissues.
- Immunogen:
- apoptotic peptidase activating factor 1
- Physical State:
- Liquid
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- GeneTex
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Manufacturer's Data Sheet:Download
