CD42b antibody [SZ2]
Product Sizes
100 ug
£429.00
GTX19655-100UG
About this Product
- SKU:
- GTX19655
- Additional Names:
- Glycoprotein Ib Platelet Subunit Alpha , Bdplt1 , Bdplt3 , Bss , Cd42B , Cd42B-Alpha , Dbplt3 , Gp1B , Gpiba , Gpibalpha , Vwdp , Gp1Ba
- Application:
- Flow Cytometry
- Buffer:
- PBS, 0.1% BSA, no preservatives.
- translate.label.attr.clone:
- SZ2
- Clonality:
- Monoclonal
- Concentration:
- 0.20 mg/ml
- Extra Details:
- Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]
- Host:
- Mouse
- Immunogen:
- Human Washed Platelets
- Isotype:
- IgG1
- Physical State:
- Liquid
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The molecular weight of the recognized antigen is 160 kDa. Reacts with glycoprotein Ib on megakaryocytesand platelets. Inhibits the ristocetin-dependent binding of Von Willebrand factor to platelets and ristocetininduced platelet agglutination. Inhibits platelet aggregation induced by Type I collagen and plateletactivating factor (PAF). Immunoprecipitates the components of glycoprotein Ib complex.
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- GeneTex
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:Download
