AKT1 (phospho Ser124) antibody [GT1268]
Product Sizes
100 ul
£486.00
GTX03180-100UL
About this Product
- SKU:
- GTX03180
- Additional Names:
- AKT serine/threonine kinase 1 , AKT , CWS6 , PKB , PKB-ALPHA , PRKBA , RAC , RAC-ALPHA
- Application:
- Western Blot
- Buffer:
- PBS, 0.05% BSA, 50% Glycerol, 0.02% Sodium azide.
- translate.label.attr.clone:
- GT1268
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1.43 mg/ml
- Extra Details:
- The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
- Host:
- Rabbit
- Immunogen:
- A phospho specific peptide corresponding to residues surrounding S124 of human AKT1.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- Based on internal testing result, this antibody does not cross with AKT2 and AKT3 proteins.
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- GeneTex
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Download
