Anti-Hu CD27 PerCP-Cy[TM]5.5
Product Sizes
25 tests
£225.00
T9-308-25TESTS
100 tests
£410.00
T9-308-100TESTS
About this Product
- SKU:
- T9-308
- Application:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- LT27
- Conjugate:
- PerCP-Cyanine 5.5
- Extra Details:
- CD27 is a transmembrane 55 kDa protein of the nerve growth factor-receptor family, expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. This sCD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70.
- Immunogen:
- Human peripheral blood lymphocytes
- Isotype:
- IgG2a
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody LT27 reacts with an extracellular epitope of CD27 (T14), a 50-55 kDa type I transmembrane glycoprotein (member of the TNF-receptor superfamily) expressed on medullary thymocytes, peripheral T lymphocytes, some B lymphocytes and NK cells.
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Exbio
- Type:
- Antibody
- FluoroFinder:
