Anti-Hu CD46 Pacific Blue[TM]
Product Sizes
25 tests
£176.00
PB-342-25TESTS
100 tests
£312.00
PB-342-100TESTS
About this Product
- SKU:
- PB-342
- Application:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MEM-258
- Conjugate:
- Pacific Blue™
- Extra Details:
- CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
- Immunogen:
- HPB-ALL human T cell line
- Isotype:
- IgG1
- Reactivities:
- Bovine, Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody MEM-258 recognizes an extracellular epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Exbio
- Type:
- Antibody
- FluoroFinder:
