Anti-gamma-Tubulin Alexa Fluor[R] 647
Product Sizes
0.025 mg
£250.00
A6-465-0.025MG
0.1 mg
£459.00
A6-465-0.1MG
About this Product
- SKU:
- A6-465
- Application:
- Flow Cytometry, Immunocytochemistry, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- TU-30
- Conjugate:
- Alexa Fluor® 647
- Concentration:
- 1 mg/ml
- Extra Details:
- The gamma-tubulin (TUBG1; relative molecular weight about 48 kDa) is a minor member of tubulin family (less that 0.01% of tubulin dimer). The gamma-tubulin ring structures, however, serve to provide structural primer for initiation of microtubular nucleation and growth, thereby being crutial for microtubule-based cellular processes, above all for mitotic spindle formation. In animal cells, a center of microtubule organization is the centrosome composed of a pair of cylindrical centrioles surrounded by fibrous pericentriolar material containing gamma-tubulin. Formation of the mitotic spindle is preceded by duplication of centrosome during S phase. Before mitosis, both centrosomes increase their microtubule nucleation capacity and form two microtuble asters that are pushed apart from each other by the forces of motor proteins associated at the microtubule surface. Humans possess two gamma-tubulin genes. Gamma-tubulin 1 represents a ubiquitous isotype, whereas gamma-tubulin 2 is found predominantly in the brain, where it may be endowed with divergent functions beyond microtubule nucleation.
- Immunogen:
- C-terminal peptide of gamma-tubulin counjugated to KLH.
- Isotype:
- IgG1
- Reactivities:
- Avian, Bovine, Human, Mouse, Parasite/Protozoa, Plant, Porcine, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody TU-30 recognizes C-terminus (amino acids 434-449 in human) of gamma-tubulin, a 48 kDa structural constituent of cytoskeleton and microtubule organizing center (MTOC). The epitope was located in the amino acid sequence TRPDYI (aa439-444 in human), which is present on human gamma-tubulin 1 but not on human gamma-tubulin 2.
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Exbio
- Type:
- Antibody
- FluoroFinder:
