Anti-SIT Alexa Fluor[R] 647
Product Sizes
0.1 mg
£459.00
A6-345-0.1MG
About this Product
- SKU:
- A6-345
- Application:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- SIT-01
- Conjugate:
- Alexa Fluor® 647
- Concentration:
- 0.1 mg/ml
- Extra Details:
- SIT is a 21 kDa transmembrane adaptor protein expressed exclusively in lymphoid organs. It acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.
- Immunogen:
- Bacterially produced recombinant intracellular fragment of human SIT.
- Isotype:
- IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody SIT-01 reacts with an intracellular epitope of SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs. It weakly crossreacts with murine SIT.
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Exbio
- Type:
- Antibody
- FluoroFinder:
