Anti-Hu CD31 FITC
Product Sizes
25 tests
£138.00
1F-273-25TESTS
100 tests
£235.00
1F-273-100TESTS
About this Product
- SKU:
- 1F-273
- Application:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MEM-05
- Conjugate:
- FITC
- Extra Details:
- CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
- Immunogen:
- Leukocytes of a patient suffering from LGL-type leukaemia
- Isotype:
- IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody MEM-05 reacts with an extracellular epitope of CD31 (PECAM-1), a 130-140 kDa type I transmembrane glycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells and stem cells of the myeloid lineage.
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Exbio
- Type:
- Antibody
- FluoroFinder:
