Anti-Hu CD148 Biotin
Product Sizes
0.025 mg
£138.00
1B-697-0.025MG
0.1 mg
£235.00
1B-697-0.1MG
About this Product
- SKU:
- 1B-697
- Application:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MEM-CD148/05
- Conjugate:
- Biotin
- Concentration:
- 1 mg/ml
- Extra Details:
- CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase, containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.
- Immunogen:
- Human recombinant CD148 (amino acids 1-444)
- Isotype:
- IgG2b
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The mouse monoclonal antibody MEM-CD148/05 recognizes an extracellular epitope of CD148, a highly glycosylated up to 250 kDa receptor-like protein tyrosin phosphatase expressed mainly in lymphocytes, myeloid cells and epithelial cells.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
