Anti-HLA-E Biotin
Product Sizes
0.025 mg
£181.00
1B-397-0.025MG
0.1 mg
£321.00
1B-397-0.1MG
About this Product
- SKU:
- 1B-397
- Application:
- Flow Cytometry, IHC-Paraffin, Immunoprecipitation
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MEM-E/07
- Conjugate:
- Biotin
- Concentration:
- 1 mg/ml
- Extra Details:
- HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).
- Immunogen:
- Bacterially expressed recombinant HLA-E refolded with beta2-microglobulin and peptide.
- Isotype:
- IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody MEM-E/07 recognizes an extracellular epitope on native surface-expressed HLA-E, but not denaturated heavy chain of HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on many types of the human cells. The published results revealed that the antibody cross-reacts with some classical MHC Class I molecules (MHC Class Ia): HLA-B7 (strongly),
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
