Anti-Hu CD45RA Biotin
Product Sizes
0.025 mg
£138.00
1B-223-0.025MG
0.1 mg
£235.00
1B-223-0.1MG
About this Product
- SKU:
- 1B-223
- Application:
- Flow Cytometry, IHC-Paraffin, Immunoprecipitation, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MEM-56
- Conjugate:
- Biotin
- Concentration:
- 1 mg/ml
- Extra Details:
- CD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed e.g. on naive T cells and normal plasma cells.
- Immunogen:
- Human thymocytes and T lymphocytes.
- Isotype:
- IgG2b
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody MEM-56 reacts with an extracellular epitope of CD45RA, a 205-220 kDa single chain type I glycoprotein, variant of CD45 (CD45RA isoform). CD45RA is expressed on most of B lymphocytes, resting and native T lymphocytes, medullar thymocytes and monocytes.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
