Anti-Hu CD25 Biotin
Product Sizes
0.025 mg
£138.00
1B-218-0.025MG
0.1 mg
£235.00
1B-218-0.1MG
About this Product
- SKU:
- 1B-218
- Application:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MEM-181
- Conjugate:
- Biotin
- Concentration:
- 1 mg/ml
- Extra Details:
- CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. Humanized anti CD25 antibodies represent a useful tool to reduce the incidence of allograft rejection as well as the severity of graft versus host reaction, and radioimmunoconjugates of anti-CD25 antibodies can be used against CD25 expressing lymphomas.
- Immunogen:
- PHA-activated peripheral blood leucocytes
- Isotype:
- IgG1, kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody MEM-181 reacts with an extracellular epitope of CD25 (Interleukin-2 receptor alpha chain), a 55 kDa type I transmembrane glycoprotein expressed on activated B and T lymphocytes, activated monocytes/macrophages and on CD4+ T lymphocytes (T regulatory cells); it is lost on resting B and T lymphocytes.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
