Anti-p53 Biotin
Product Sizes
0.1 mg
£235.00
1B-114-0.1MG
About this Product
- SKU:
- 1B-114
- Application:
- ELISA, Flow Cytometry, IHC-Paraffin, Immunocytochemistry, Immunoprecipitation, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- BP53-12
- Conjugate:
- Biotin
- Concentration:
- 1 mg/ml
- Extra Details:
- The tumour suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest, or proteins that trigger apoptosis, such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain, central DNA-binding domain, oligomerisation domain, and C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization.
- Immunogen:
- Bacterially expressed full-length wild-type p53
- Isotype:
- IgG2a
- Reactivities:
- Human, Non-human Primate
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody BP53-12 recognizes a defined epitope (aa 16-25) on human p53, a 50 kDa intracellular tumour suppressor found in increased amounts in a wide variety of transformed cells; it is frequently mutated or inactivated in many types of cancer.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
