Anti-Ms CD45 APC
Product Sizes
0.025 mg
£159.00
1A-553-0.025MG
0.1 mg
£278.00
1A-553-0.1MG
About this Product
- SKU:
- 1A-553
- Application:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- EM-05
- Conjugate:
- APC
- Concentration:
- 0.5 mg/ml
- Extra Details:
- CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
- Immunogen:
- Murine peripheral blood leukocytes
- Isotype:
- IgG
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- The rat monoclonal antibody EM-05 reacts with an extracellular epitope of murine CD45 antigen (Leukocyte Common Antigen), a single chain type I transmembrane protein expressed at high level on cells of hematopoietic origin, except erythrocytes and platelets.
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Exbio
- Type:
- Antibody
- FluoroFinder:
