Anti-Hu CD79a APC
Product Sizes
25 tests
£159.00
1A-530-25TESTS
100 tests
£278.00
1A-530-100TESTS
About this Product
- SKU:
- 1A-530
- Application:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- HM57
- Conjugate:
- APC
- Extra Details:
- CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
- Immunogen:
- Synthetic peptide corresponding to amino acids 202-216 of human CD79a
- Isotype:
- IgG1
- Reactivities:
- Avian, Bovine, Guinea Pig, Horse, Human, Mouse, Other Mammal, Porcine, Rabbit, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody HM57 interacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Exbio
- Type:
- Antibody
- FluoroFinder:
