Anti-Hu CD95 APC
Product Sizes
25 tests
£159.00
1A-362-25TESTS
100 tests
£278.00
1A-362-100TESTS
About this Product
- SKU:
- 1A-362
- Application:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- LT95
- Conjugate:
- APC
- Extra Details:
- CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.
- Immunogen:
- HUT-78 human T cell lymphoma cell line
- Isotype:
- IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody LT95 reacts with an extracellular epitope on CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a function
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Exbio
- Type:
- Antibody
- FluoroFinder:
