Anti-Hu CD88 Purified
Product Sizes
0.025 mg
£111.00
11-736-0.025MG
0.1 mg
£181.00
11-736-0.1MG
About this Product
- SKU:
- 11-736
- Application:
- Flow Cytometry, IHC-Paraffin, Immunoprecipitation, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- S5/1
- Concentration:
- 1 mg/ml
- Extra Details:
- CD88 / C5aR is a G protein-coupled seven membrane-spanning protein serving as a receptor for C5a component of the complement cascade, and is expressed mainly by monocytes, macrophages, neutrophils, eosinophils, and mast cells, but also e.g. by hepatocytes, glial cells, vascular endothelial cells, or cardiomyocytes. The binding of C5a to CD88 is associated with inflammatory response, including superoxide anion production, chemotaxis, and increased production of acute phase proteins. Expression of CD88 on synovial mast cells and their C5a-mediated degranulation plays a role in pathogenesis of rheumatoid arthritis.
- Immunogen:
- Recombinant N-terminal peptide (Asp15-Asp27) of human C5aR
- Isotype:
- IgG2a, kappa
- Reactivities:
- Bovine, Human, Other Mammal, Rabbit
- Shipping Conditions:
- Blue Ice
- Specificity:
- The mouse monoclonal antibody S5/1 recognizes an extracellular epitope of CD88 protein, a 43 kDa receptor of C5a component of the complement cascade.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
