Anti-Hu CD79a Purified
Product Sizes
0.025 mg
£116.00
11-731-0.025MG
0.1 mg
£192.00
11-731-0.1MG
About this Product
- SKU:
- 11-731
- Application:
- Flow Cytometry, IHC-Paraffin, Immunoprecipitation, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- HM47
- Concentration:
- 1 mg/ml
- Extra Details:
- CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
- Immunogen:
- Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
- Isotype:
- IgG1, kappa
- Reactivities:
- Avian, Bovine, Canine, Guinea Pig, Horse, Human, Mouse, Non-human Primate, Porcine, Rabbit, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- The mouse monoclonal antibody HM47 reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
