Anti-Drebrin Purified
Product Sizes
0.025 mg
£138.00
11-694-0.025MG
0.1 mg
£235.00
11-694-0.1MG
About this Product
- SKU:
- 11-694
- Application:
- Flow Cytometry, Mass Cytometry, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- DBN-N-03
- Concentration:
- 1 mg/ml
- Extra Details:
- Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.
- Immunogen:
- Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
- Isotype:
- IgG2b
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The mouse monoclonal antibody DBN-N-03 recognizes drebrin, an approximately 100-125 kDa intracellular regulator of actin cytoskeleton.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
