Anti-Granzyme B Purified
Product Sizes
0.1 mg
£224.00
11-634-0.1MG
About this Product
- SKU:
- 11-634
- Application:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- CLB-GB11
- Concentration:
- 1 mg/ml
- Extra Details:
- Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.
- Immunogen:
- Human NK cell line YT-INDY-derived granzyme B
- Isotype:
- IgG1
- Reactivities:
- Human, Non-human Primate
- Shipping Conditions:
- Blue Ice
- Specificity:
- The mouse monoclonal antibody CLB-GB11 recognizes granzyme B, a 31 kDa serine protease expressed intracellularly in activated Tc cells and NK cells.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
