Anti-Hu EGFR (pY992) Purified
Product Sizes
0.025 mg
£138.00
11-574-0.025MG
0.1 mg
£235.00
11-574-0.1MG
About this Product
- SKU:
- 11-574
- Application:
- Flow Cytometry, Immunoprecipitation, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- EM-12
- Concentration:
- 1 mg/ml
- Extra Details:
- The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.
- Immunogen:
- Synthetic phospho-peptide covering sequence around tyrosine 992 of human EGFR.
- Isotype:
- IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The mouse monoclonal antibody EM-12 reacts with human EGFR (ErbB1 / HER1) phosphorylated on intracellular tyrosine 992.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
